2021
Liu Y, Liu J, Plante KS, Plante JA, Xie X, Zhang X, Ku Z, An Z, Scharton D, Schindewolf C, Menachery VD, Shi PY, Weaver SC. The N501Y spike substitution enhances SARS-CoV-2 transmission. Nature. Nature. 2021 Nov 24. doi: 10.1038/s41586-021-04245-0.
Vanderheiden A, Thomas J, Soung AL, Davis-Gardner ME, Floyd K, Jin F, Cowan DA, Pellegrini K, Creanga A, Pegu A, Derrien-Colemyn A, Shi PY, Grakoui A, Klein RS, Bosinger SE, Kohlmeier JE, Menachery VD, Suthar MS. CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection. mBio. 2021 Nov 9:e0274921. doi: 10.1128/mBio.02749-21.
Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugmage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Xie X, Shi PY, Menachery VD. Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge. PLoS Biol. 2021 Nov 4;19(11):e3001284. doi: 10.1371/journal.pbio.3001284. PMID: 34735434.
Jaworski E, Langsjoen RM, Judy B, Newman P, Plante JA, Plante KS, Miller AL, Zhou Y, Swetnam D, Dong J, Ren P, Pyles RB, Ksiazek T, Menachery VD, Weaver SC, Routh A. Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants. Elife. 2021 Sep 28;10:e68479. doi: 10.7554/eLife.68479. PMID: 34581669.
Vu MN, Menachery VD. Binding and Entering: COVID finds a new home. PlosPathogen. 2021 Aug 30;17(8):e1009857. PMC8404997.
Pegu A, O'Connell S, Schmidt SD, O'Dell S, Talana CA, Lai L, Albert J, Anderson E, Bennett H, Corbett KS, Flach B, Jackson L, Leav B, Ledgerwood JE, Luke CJ, Makowski M, Nason MC, Roberts PC, Roederer M, Rebolledo PA, Rostad CA, Rouphael NG, Shi W, Wang L, Widge AT, Yang ES; mRNA-1273 Study Group, Beigel JH, Graham BS, Mascola JR, Suthar MS, McDermott AB, Doria-Rose NA. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science. 2021 Aug 12:eabj4176. doi: 10.1126/science.abj4176. Epub ahead of print. PMID: 34385356
Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineria E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AEL, Malhorta U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Bailie JK, Buckner JH, Galer M, Savan R. Endomembrane targeting of human OASI p46 augments antiviral activity. Elife. 2021 Aug 3;10:e71047. PMC8357416.
Matchett WE, Joag V, Stolley JM, Shepherd FK, Quarnstrom CF, Mickelson CK, Wijeyesinghe S, Soerens AG, Becker S, Thiede JM, Weyu E, O’Flanagan SD, Walter JA, Vu MN, Menachery VD, Boyd TD, Vezy V, Jenkins MK, Langlois RA, Masopust D. Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity. Journal of Immunology. June 30, 2021, ji2100421. doi: 10.4049/jimmunol.2100421.
Routhu NK, Cheedarla N, Bollimpelli VS, Gangadhara S, Edara VV, Lai L, Sahoo A, Shiferaw A, Styles TM, Floyd K, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Dinnon KH 3rd, Shi PY, Menachery VD, Tomai M, Fox CB, Alter G, Vanderford TH, Gralinski L, Suthar MS, Amara RR. SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung. Nat Commun. 2021 Jun 11;12(1):3587. PMC8196016.
Menachery VD, Gralinski LE. Coagulation and wound repair during COVID-19. J Heart Lung Transplant. 2021 Jun 12:S1053-2498(21)02359-7. PMC8195688.
Doria-Rose N, Suthar MS, Makowski M, O'Connell S, McDermott AB, Flach B, Ledgerwood JE, Mascola JR, Graham BS, Lin BC, O'Dell S, Schmidt SD, Widge AT, Edara VV, Anderson EJ, Lai L, Floyd K, Rouphael NG, Zarnitsyna V, Roberts PC, Makhene M, Buchanan W, Luke CJ, Beigel JH, Jackson LA, Neuzil KM, Bennett H, Leav B, Albert J, Kunwar P; mRNA-1273 Study Group. Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19. N Engl J Med. 2021 Jun 10;384(23):2259-2261. doi: 10.1056/NEJMc2103916. Epub 2021 Apr 6. PMID: 33822494.
Ku Z, Xie X, Hinton PR, Liu X, Ye X, Muruato AE, Ng DC, Biswas S, Zou J, Liu Y, Pandya D, Menachery VD, Rahman S, Cao YA, Deng H, Xiong W, Carlin KB, Liu J, Su H, Haanes EJ, Keyt BA, Zhang N, Carroll SF, Shi PY, An Z. Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants. Nature. 2021 Jul;595(7869):718-723. doi: 10.1038/s41586-021-03673-2. Epub 2021 Jun 3.
Trimarco JD, Heaton BE, Chaparian RR, Burke KN, Binder RA, Gray GC, Smith CM, Menachery VD, Heaton NS. TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. PLoS Pathog. 2021 May 27;17(5):e1009599.; PMCID: PMC8189496.
Lakdawala SS, Menachery VD. Catch me if you can: Superspreading of SARS-CoV-2. Trends Microbiol. 2021 May 11:S0966-842X(21)00124-4. PMC8112283.
Feng S, Heath E, Jefferson B, Joslyn C, Kvinge H, Mitchell HD, Praggastis B, Eisfeld AJ, Sims AC, Thackray LB, Fan S, Walters KB, Halfmann PJ, Westhoff-Smith D, Tan Q, Menachery VD, Sheahan TP, Cockrell AS, Kocher JF, Stratton KG, Heller NC, Bramer LM, Diamond MS, Baric RS, Waters KM, Kawaoka Y, McDermott JE, Purvine E. Hypergraph models of biological networks to identify genes critical to pathogenic viral response. BMC Bioinformatics. 2021 May 29;22(1):287. PMC8164482.
Mantus G, Nyhoff LE, Kauffman RC, Edara VV, Lai L, Floyd K, Shi PY, Menachery VD, Edupuganti S, Scherer EM, Kay A, McNair N, Anderson EJ, Rouphael N, Ahmed R, Suthar MS, Wrammert J. Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain. J Immunol 2021 May 5;ji2001420. doi: 10.4049/jimmunol.2001420.
Zhang X, Liu Y, Liu J, Bailey AL, Plante KS, Plante JA, Zou J, Xia H, Bopp N, Aguilar P, Ren P, Menachery VD, Diamond MS, Weaver SC, Xie X, Shi PY. A trans -complementation system for SARS-CoV-2. Cell. 2021 Apr 15; 184(8): 2229–2238.e13. PMC7901297.9.
Plante JA, Mitchell BM, Plante KS, Debbink K, Weaver SC, Menachery VD. The variant gambit: COVID-19’s next move. Cell Host Microbe. 2021 Mar 1:S1931-3128(21)00099-8. PMC7919536.
Routhu NK, Cheedarla N, Gangadhara S, Bollimpelli VS, Boddapati AK, Shiferaw A, Rahman SA, Sahoo A, Edara VV, Lai L, Floyd K, Wang S, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Upadhyay AA, Pellegrini K, Montefiori D, Shi PY, Menachery VD, Alter G, Vanderford TH, Bosinger SE, Suthar MS, Amara RR. A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. Immunity. 2021 Mar 9;54(3):542-556.e9. PMC7859620.
Xie X, Liu Y, Liu J, Zhang X, Zou J, Fontes-Garfias CR, Xia H, Swanson KA, Cutler M, Cooper D, Menachery VD, Weaver SC, Dormitzer PR, Shi PY. Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. Nat Med. 2021 Feb 8. doi: 10.1038/s41591-021-01270-4.
Graham JB, Swarts JL, Leist SR, Schäfer A, Menachery VD, Gralinski LE, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Heise MT, Baric RS, Lund JM. Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice. PLoSPathog. 2021 Jan 29;17(1):e1009287. PMC7875398.
Fiege JK, Theide JM, Nanda HA, Matchett WE, Moore PJ, Montanari NR, Thielen BK, Daniel J, Stanley E, Hunter RC, Menachery VD, Shen SS, Bold TD, Langlois RA. Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium. PLoSPathog. 2021 Jan 28;17(1):e1009292. PMC7872261.
Xie X, Lokugamage KG, Zhang X, Vu MN, Menachery VD*, Shi PY*. Engineering SARS-CoV-2 using a reverse genetic system. Nature Protocols. 2021 Jan 29. doi: 10.1038/s41596-021-00491-8. PMID:. *Co-senior authors.
Johnson BA, Xie X, Kalveram B, Lokugamage KG, Muruato A, Zou J, Zhang X, Juelich T, Smith JK, Zhang L, Bopp N, Schindewolf C, Vu M, Vanderheiden A, Swetnam D, Plante JA, Aguilar P, Plante KS, Lee B, Weaver SC, Suthar MS, Routh AL, Ren P, Ku Z, An Z, Debbink K, Shi PY, Freiberg AN, Menachery VD. Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis. Nature. 2021 Jan 25. PMID: 33494095
Ku Z, Xie X, Davidson E, Ye X, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z. Molecular determinats and mechanism for antibody cocktail preventing SARS-CoV-2 escape. Nat. Commun. 2021 Jan 20;12 (1):469. PMC7817669.
2020
Plante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY. Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility. Nature. . 2020 Oct 26. PMID: 33106671
Xie X, Muruato AE, Zhang X, Lokugamage KG, Fontes-Garfias CR, Zou J, Liu J, Ren P, Balakrishnan M, Cihlar T, Tseng CK, Makino S, Menachery VD, Bilello JP, Shi PY. 2020. A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19. Nature Commun. 2020 11, 5214. PMID: 33060595
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY. Evasion of Type I Interferon by SARS-CoV-2. Cell Rep. 2020 Oct 6;33(1):108234. PMID: 32979938
Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Jenkins MK, Menachery VD, Langlois RA, Bold TD. 2020. SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease Transfusion. 2020 Sep 16. PMID: 32935872
Rostad CA, Chahroudi A, Mantus G, Lapp SA, Teherani M, Macoy L, Tarquinio KM, Basu RK, Kao C, Linman WM, Zimmerman MG, Shi PY, Menachery VD, Oster ME, Edupuganti S, Anderson EJ, Suthar M, Wrammert J, Jaggi P. Quantitative SARS-CoV-2 Serology in Children with Multisystem Inflammatory Syndrome (MIS-C). Pediatrics. 2020 Sep 2:e2020018242. PMID: 32879033
Muruato AE, Fontes-Garfias CR, Ren P, Garcia-Blanco MA, Menachery VD, Xie X, Shi PY. 2020. A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation. Nat Commun. 2020 Aug 13;11(1):4059. PMID: 32792628
Prasanth KR, Hirano M, Fagg WS, McAnarney ET, Shan C, Xie X, Hage A, Pietzsch CA, Bukreyev A, Rajsbaum R, Shi PY, Bedford MT, Bradrick SS, Menachery V, Garcia-Blanco MA. 2020. Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses. Antiviral Res. 2020 Jul 28;182:104874. PMID: 32735900
Vanderheiden A, Ralfs P, Chirkova T, Upadhyay AA, Zimmerman MG, Bedoya S, Aoued H, Tharp GM, Pellegrini KL, Manfredi C, Sorscher E, Mainou B, Lobb JL, Kohlmeier JE, Lowen AC, Shi PY, Menachery VD, Anderson LJ, Grakoui A, Bosinger SE, Suthar MS. Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. J Virol. 2020;JVI.00985-20. PMID: 32699094
Suthar MS, Zimmerman MG, Kauffman RC, Mantus G, Linderman SL, Hudson WH, Vanderheiden A, Nyhoff L, Davis CW, Adekunle O, Affer M, Sherman M, Reynolds S, Verkerke HP, Alter DN, Guarner J, Bryksin J, Horwath MC, Arthur CM, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson EJ, Menachery VD, Rouphael N, Mehta AK, Stephens DS, Ahmed R, Roback JD, Wrammert J. 2020. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Reports Medicine 1:100040. 32835303
Sandler ZJ, Firpo MR, Omoba OS, Vu MN, Menachery VD, Mounce BC. Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening. Antimicrob Agents Chemother. 2020;64(6):e00086-20. PMID: 32284379
Lakdawala SS, Menachery VD. The search for a COVID-19 animal model. Science. 2020;368(6494):942-94. PMID: 32467379
Noll KE, Whitmore AC, West A, McCarthy MK, Morrison CR, Plante KS, Hampton BK, Kollmus H, Pilzner C, Leist SR, Gralinski LE, Menachery VD, Schäfer A, Miller D, Shaw G, Mooney M, McWeeney S, Pardo-Manuel de Villena F, Schughart K, Morrison TE, Baric RS, Ferris MT, Heise MT. 2020. Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Rep 31:107587. PMID: 32348764
Xie X, Muruato A, Lokugamage KG, Narayanan K, Zhang X, Zou J, Liu J, Schindewolf C, Bopp NE, Aguilar PV, Plante KS, Weaver SC, Makino S, LeDuc JW, Menachery VD*, Shi PY*. An Infectious cDNA Clone of SARS-CoV-2. Cell Host Microbe. 2020;27(5):841-848.e3. *Co-Senior Authors. PMID: 32289263
Harcourt J, Tamin A, Lu X, Kamili S, Sakthivel SK, Murray J, Queen K, Tao Y, Paden CR, Zhang J, Li Y, Uehara A, Wang H, Goldsmith C, Bullock HA, Wang L, Whitaker B, Lynch B, Gautam R, Schindewolf C, Lokugamage KG, Scharton D, Plante JA, Mirchandani D, Widen SG, Narayanan K, Makino S, Ksiazek TG, Plante KS, Weaver SC, Lindstrom S, Tong S, Menachery VD*, Thornburg NJ*. Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States. Emerg Infect Dis. 2020;26(6):1266-1273. *Co-Senior Authors. PMID: 32160149
Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses. 2020 Jan 24;12(2). pii: E135. doi: 10.3390/v12020135. PMID: 31991541
Menachery VD*, Dinnon KH*, Yount BL, McAnarney ET, Gralinski LE, Hale A, Graham RL, Scobey T, Anthony SJ, Corti D, Graham B, Lipkin WI, Baric RS. Trypsin treatment unlocks barrier for zoonotic coronavirus infection. J. Virol. 2019 Dec 4. Pii: JVI.01774-19. doi: 10.1128/JVI.01774-19. PMID: 31801868
Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schaefer A, Plante K, Morrison C, Voss K, Green R, Choonoo G, Jeng S, Miller DR, Mooney M, McWeeney S, Ferris MT, Pardo Manuel de Villena F, Gale M, Baric RS, Heise M, Lund JM. Universal Immune Predictors of Mortality Following Virus Infection. J Infect Dis. 2019 Oct 17. pii: jiz531. PMID: 31621854
2019
Johnson BA, Hage A, Kalveram B, Mears M, Plante JA, Rodriguez SE, Ding Z, Bente D, Bradrick S, Freiberg AN, Popov V, Rajsbaum R, Rossi S, Russell WK, Menachery VD. Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity. J Virol. 2019 Aug 28. pii: JVI.01282-19. doi: 10.1128/JVI.01282-19. PMID: 31462558
2014
Selinger C, Tisoncik-Go J, Menachery VD, Agnihothrum S, Law GL, Chang J, Kelly SM, Sova P, Baric RS, Katze MG. Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates. BMC Genomics. 2014 Dec 22;15(1):1161. PMID 25534508.
Menachery VD, Debbink K, Baric RS. Coronavirus Non-Structural Protein 16: Evasion, Attenuation, and Possible Treatments. Virus Research. 2014 Sep 30; pii: S0168-1702(14)00396-7. PMID 25278144.
Aevermann B, Pickett B, Kumar S, Klem E, Agnihothrum S, Askovich P, Bankhead A, Bolles M, Carter V, Chang J, Clauss T, Dash P, Diercks A, Eisfeld A, Ellis A, Fan S, Ferris M, Gralinski L, Green R, Gritsenko M, Hatta M, Heegel R, Jacobs J, Jeng S, Josset L, Kaiser S, Kelly S, Law G, Li C, Li J, Long C, Luna M, Matzke M, McDermott J, Menachery V, Metz T, Mitchell H, Monroe M, Navarro G, Neumann G, Podyminogin R, Purvine S, Rosenberger C, Sanders C, Schempmoes A, Shukla A, Sims A, Sova P, Tam V, Tchitchek N, Thomas P, Tilton S, Totrua A, Wang J, Webb-Robertson B, Wen J, Weiss J, Yang F, Yount B, Zhang Q, McWeeney S, Smith R, Water K, Kawaoka Y, Baric R, Aderem A, Katze M, Scheuermann R. A Comprehensive collection of systems biology data characterizing the host response to viral infection. Scientific Data. 2014 Oct. 14;1: 140033. PMID 25977790.
Menachery VD, Eisfeld AJ, Josset L, Sims AC, Schaefer A, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Matzke MM, Webb-Robertson BJ, Shukula AK, Burkett S, Metz TO, Pickles R, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS. Pathogenic influenza and coron aviruses utilize similar and contrasting approaches to control global interferon stimulated gene responses. MBio. 2014 May 20; 5(3): e01174-14. PMID 24846384.
Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio. 2014 Mar 25; 5(2): e00047-14. PMID 24667706.
Menachery VD, Yount BL, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze M, Baric RS. Attenuation and Restoration of SARS-CoV Mutant lacking 2’O Methyltransferase Activity. J Virol. 2014 Apr;88(8):4251-64. PMID 24478444.
2013
Agnihothram S, Gopal R, Yount B Jr, Donaldon EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. 2013. Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses. J Infect Dis. 2013 Dec 30. PMID 24253287.
Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. PMID 24043791.
Menachery VD, Baric RS. Bugs in the System. Immunol Rev. 2013 Sep: 255(1):256-74. PMID 2394736.
Gralinski LE, Bankhead A, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio. 2013 Aug 6;4(4). PMID 23919993.
Menachery VD*, Josset L*, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus. MBio. 2013 Apr 30; 4(3). *Co-first authors. PMID 23631916.
Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS. Release of SARS-CoV nuclear import block enhances host transcription in human lung cells. J Virol. 2013 Apr; 87(7):3885-902. PMID 23365422.
2008-2012
Pasieka, TJ, Menachery VD, Rosato PC, Leib DA. Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus type 1 in the absence of virion host shutoff. J Virol. 2012 Jul; 86(14):7692-5. PMID 22553331.
Menachery VD, Pasieka TJ, Leib DA. Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. J Virol. 2010 Oct; 84(19): 9685-94. Epub 2010 Jul 21. PMID 20660188.
Menachery VD, Leib DA. Control of herpes simplex virus replication is mediated through an IRF-3 dependent pathway. J Virol. 2009 Dec; 83(23): 12399-406. PMID 19759149.
Pasieka TJ, Lu B, Crosby SD, Wylie KM, Morrison LA, Alexander DE, Menachery VD, Leib DA. Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state. J Virol. 2008 Jun;82(11):5527-35. PMID 18367525.
Dinnon KH, Gallichotte EN, Fritch EJ, Menachery VD, Baric RS. Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity. Plos Neglected Tropical Diseases. 2019 Mar 7; 13(3):e007212. PMID: 30845254.
Schindewolf C, Menachery VD. Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism. Viruses. 2019 Jan 17; 11(1). Pii: E74. PMID: 30658390.
2018
Van Doremalen N, Schaefer A, Menachery VD, Letko M, Bushmaker T, Fischer R, Figueroa D, Hanley P, Saturday G, Baric RS, Munster V. SARS-like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses. 2018 Dec 19; 10(12). Pii:E727. PMID: 30572566.
Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Whitmore A, Heise MT, Baric RS. Complement activation contributes to SARS-Coronavirus pathogenesis. MBio. 2018 Oct 9;9(5). pii: e01753-18. PMID: 30301856.
Van Doremalen N, Schaefer A, Menachery VD, Letko M, Bushmaker T, Fischer R, Figueroa D, Hanley P, Saturday G, Baric RS, Munster V. SARS-like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses. 2018 Dec 19; 10(12). Pii:E727
Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, McAnarney ET, Graham RL, Waters KM, Baric RS. Combination attenuation offers strategy for live-attenuated coronavirus vaccines. J Virol. 2018 Aug 16;92(17). pii: e00710-18. PMID: 29976657.
McMullan RC, Ferris MT, Bell TA, Menachery VD, Baric RS, Hua K, Pomp D, Smith-Ryan A, Pardo-Manuel de Vilena F. CC002/Unc females are mouse models of exercise-induced adverse fat response. Physiol Rep. 2018 Jun;6(12):e13716. PMID: 29924460.
Menachery VD*, Agnihothrum S, Yount BL, Lindesmith LC, Whitmore A, Schaefer A, Heise MT, Baric RS. Development of a broadly accessible VEE Replicon Particle Vaccine Platform. J. Virol. 2018 May 14;92(11). pii: e00027-18. *Co-first authors. PMID: 29540599.
Johnson BA, Graham RL, Menachery VD. Metagenomics, structure, and reverse genetics: Key platforms for emerging coronavirus research. Virology. 2017 Dec 23. pii: S0042-6822(17)30414-2. PMID: 29279138.
2017
Menachery VD, Gralinski LE, Dinnon KH, Mitchell HD, Dinnon KD, Leist SR, Yount BL, Graham RL, McAnarney ET, Stratton KG, Debbink K, Sims AC, Waters KM, Baric RS. MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis. Msphere 2017. PMID: 29152578. Summary Prezi
Gallichotte EN, Dinnon KH, Lim XN, Ng TS, Lim E, Menachery VD, Kok SM Lok, Baric RS. CD-loop extension in Zika virus envelope key for stability and pathogenesis. J Infect Dis. 2017 Sep 8. PMID 28968838.
Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS. MERS-CoV Accessory ORFs play key role for infection and pathogenesis. MBio. 2017 Aug 22;8(4). pii: e00665-17. PMID 28830941. Summary Prezi
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibit both epidemic and zoonotic coronavirus. Science Translation Medicine, 2017 Jun 28;9(396). pii: eaal3653. PMID 28659436.
Gralinski LE, Menachery VD, Morgan AP, Totura AL, Beall A, Kocher J, Plante J, Harrison-Shostak DC, Schaefer A, Pardo-Manuel de Vilena F, Ferris MT, Baric RS. Allelic Variation in Ticam2 contributes to SARS-CoV pathogenesis. G3 (Bethesda), 017 Jun 7;7(6):1653-1663. PMID 28592648.
Anthony SJ, Gilardi K, Menachery VD, Goldstein T, Ssebide B, Mbabazi R, Navarrete-Macias I, Liang E, Wells H, Hicks A, Petrosov A, Byarugaba DK, Debbink K, Dinnon KH, Scobey T, Randell SH, Yount BL, Cranfield M, Johnson CK, Baric RS, Lipkin WI, Mazet JAK. Further evidence for bats as the evolutionary source of MERS Coronavirus. MBio. 2017 Apr 4;8(2). pii: e00373-17. PMID 28377531.
Menachery VD*, Gallichotte EN*, Dinnon KH, Yount BL, Hartman S, Widman D, Messer W, de Silva A, Baric RS. Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone. mSphere. 2017 Feb 22;2(1). pii: e00380-16. *Co-first authors. PMID 28251184.
Menachery VD, Graham RL, Baric RS. Jumping species – a mechanism for coronavirus survival. Current Opinion in Virology. 2017 Feb 16;23:1-7. PMID 28214731.
2016
Menachery VD, Yount BL, Sims AC, Agnihothram SA, Gralinski LE, Plante JA, Graham RL, Scobey T, Royal S, Pickles RJ, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. SARS-like WIV1-CoV poised for human emergence, but may lack epidemic potential. PNAS. 2016 Mar 14. pii: 201517719. PMID 26976607.
*Article Commentary by Vincent Racaniello: PMID 26976606
2015
Menachery VD, Gralinski LE, Baric RS, Ferris MT. New Metrics for Evaluating Respiratory Pathogenesis. PlosOne. 2015 June 26; 10(6): e0131451. PMID 26115403.
Schindewolf C, Menachery VD. Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism. Viruses. 2019 Jan 17; 11(1). Pii: E74. PMID: 30658390.
2018
Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Whitmore A, Heise MT, Baric RS. Complement activation contributes to SARS-Coronavirus pathogenesis. MBio. 2018 Oct 9;9(5). pii: e01753-18. PMID: 30301856.
Van Doremalen N, Schaefer A, Menachery VD, Letko M, Bushmaker T, Fischer R, Figueroa D, Hanley P, Saturday G, Baric RS, Munster V. SARS-like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus). Viruses. 2018 Dec 19; 10(12). Pii:E727
Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH, Leist SR, Yount BL, McAnarney ET, Graham RL, Waters KM, Baric RS. Combination attenuation offers strategy for live-attenuated coronavirus vaccines. J Virol. 2018 Aug 16;92(17). pii: e00710-18. PMID: 29976657.
Menachery VD*, Agnihothrum S, Yount BL, Lindesmith LC, Whitmore A, Schaefer A, Heise MT, Baric RS. Development of a broadly accessible VEE Replicon Particle Vaccine Platform. J. Virol. 2018 May 14;92(11). pii: e00027-18. *Co-first authors. PMID: 29540599.
Menachery VD, Schaefer A, Burnum-Johnson KE,Mitchell HD, Eisfeld AJ, Walters KB, Nocra CD, Purvine
SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski
LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS. MERS-CoV and
H5N1 influenza virus antagonize antigen presentation by altering the epigenetic
landscape. PNAS. 2018 Jan
30;115(5):E1012-E1021. PMID: 29339515. Summary Prezi
Johnson BA, Graham RL, Menachery VD. Metagenomics, structure, and reverse genetics: Key platforms for emerging coronavirus research. Virology. 2017 Dec 23. pii: S0042-6822(17)30414-2. PMID: 29279138.
2017
Menachery VD, Gralinski LE, Dinnon KH, Mitchell HD, Dinnon KD, Leist SR, Yount BL, Graham RL, McAnarney ET, Stratton KG, Debbink K, Sims AC, Waters KM, Baric RS. MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis. Msphere 2017. PMID: 29152578. Summary Prezi
Gallichotte EN, Dinnon KH, Lim XN, Ng TS, Lim E, Menachery VD, Kok SM Lok, Baric RS. CD-loop extension in Zika virus envelope key for stability and pathogenesis. J Infect Dis. 2017 Sep 8. PMID 28968838.
Menachery VD, Mitchell HD, Cockrell AS, Gralinski LE, Yount BL, Graham RL, McAnarney ET, Douglas MG, Scobey T, Beall A, Dinnon K, Kocher JF, Hale AE, Stratton KG, Waters KM, Baric RS. MERS-CoV Accessory ORFs play key role for infection and pathogenesis. MBio. 2017 Aug 22;8(4). pii: e00665-17. PMID 28830941. Summary Prezi
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibit both epidemic and zoonotic coronavirus. Science Translation Medicine, 2017 Jun 28;9(396). pii: eaal3653. PMID 28659436.
Gralinski LE, Menachery VD, Morgan AP, Totura AL, Beall A, Kocher J, Plante J, Harrison-Shostak DC, Schaefer A, Pardo-Manuel de Vilena F, Ferris MT, Baric RS. Allelic Variation in Ticam2 contributes to SARS-CoV pathogenesis. G3 (Bethesda), 017 Jun 7;7(6):1653-1663. PMID 28592648.
Anthony SJ, Gilardi K, Menachery VD, Goldstein T, Ssebide B, Mbabazi R, Navarrete-Macias I, Liang E, Wells H, Hicks A, Petrosov A, Byarugaba DK, Debbink K, Dinnon KH, Scobey T, Randell SH, Yount BL, Cranfield M, Johnson CK, Baric RS, Lipkin WI, Mazet JAK. Further evidence for bats as the evolutionary source of MERS Coronavirus. MBio. 2017 Apr 4;8(2). pii: e00373-17. PMID 28377531.
Menachery VD*, Gallichotte EN*, Dinnon KH, Yount BL, Hartman S, Widman D, Messer W, de Silva A, Baric RS. Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone. mSphere. 2017 Feb 22;2(1). pii: e00380-16. *Co-first authors. PMID 28251184.
Menachery VD, Graham RL, Baric RS. Jumping species – a mechanism for coronavirus survival. Current Opinion in Virology. 2017 Feb 16;23:1-7. PMID 28214731.
2016
Menachery VD, Yount BL, Sims AC, Agnihothram SA, Gralinski LE, Plante JA, Graham RL, Scobey T, Royal S, Pickles RJ, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. SARS-like WIV1-CoV poised for human emergence, but may lack epidemic potential. PNAS. 2016 Mar 14. pii: 201517719. PMID 26976607.
*Article Commentary by Vincent Racaniello: PMID 26976606
2015
Menachery VD. MERS vaccine candidate offers promise, but questions remain. E-Biomedicine. Commentary. PMID 26629514.
Menachery VD, Yount BL, Debbink K, Agnihothrum SA, Gralinski LE, Graham RL, Plante JA, Scobey T, Donaldson E, Ge XY, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. SARS-like cluster of circulating bat coronaviruses pose a threat for human emergence. Nature Medicine. Dec;21 (12): 1508-13. PMID 26552008
Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman M, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Vilena F, Baric RS. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PlosGenetics. 2015 Oct 9; 11(10):e1005504. PMID 26452100.
2014
Selinger C, Tisoncik-Go J, Menachery VD, Agnihothrum S, Law GL, Chang J, Kelly SM, Sova P, Baric RS, Katze MG. Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates. BMC Genomics. 2014 Dec 22;15(1):1161. PMID 25534508.
Menachery VD, Debbink K, Baric RS. Coronavirus Non-Structural Protein 16: Evasion, Attenuation, and Possible Treatments. Virus Research. 2014 Sep 30; pii: S0168-1702(14)00396-7. PMID 25278144.
Aevermann B, Pickett B, Kumar S, Klem E, Agnihothrum S, Askovich P, Bankhead A, Bolles M, Carter V, Chang J, Clauss T, Dash P, Diercks A, Eisfeld A, Ellis A, Fan S, Ferris M, Gralinski L, Green R, Gritsenko M, Hatta M, Heegel R, Jacobs J, Jeng S, Josset L, Kaiser S, Kelly S, Law G, Li C, Li J, Long C, Luna M, Matzke M, McDermott J, Menachery V, Metz T, Mitchell H, Monroe M, Navarro G, Neumann G, Podyminogin R, Purvine S, Rosenberger C, Sanders C, Schempmoes A, Shukla A, Sims A, Sova P, Tam V, Tchitchek N, Thomas P, Tilton S, Totrua A, Wang J, Webb-Robertson B, Wen J, Weiss J, Yang F, Yount B, Zhang Q, McWeeney S, Smith R, Water K, Kawaoka Y, Baric R, Aderem A, Katze M, Scheuermann R. A Comprehensive collection of systems biology data characterizing the host response to viral infection. Scientific Data. 2014 Oct. 14;1: 140033. PMID 25977790.
Menachery VD, Eisfeld AJ, Josset L, Sims AC, Schaefer A, Proll S, Fan S, Li C, Neumann G, Tilton SC, Chang J, Gralinski LE, Long C, Green R, Matzke MM, Webb-Robertson BJ, Shukula AK, Burkett S, Metz TO, Pickles R, Smith RD, Waters KM, Katze MG, Kawaoka Y, Baric RS. Pathogenic influenza and coron aviruses utilize similar and contrasting approaches to control global interferon stimulated gene responses. MBio. 2014 May 20; 5(3): e01174-14. PMID 24846384.
Agnihothram S, Yount BL Jr, Donaldson EF, Huynh J, Menachery VD, Gralinski LE, Graham RL, Becker MM, Tomar S, Scobey TD, Osswald HL, Whitmore A, Gopal R, Ghosh AK, Mesecar A, Zambon M, Heise M, Denison MR, Baric RS. A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio. 2014 Mar 25; 5(2): e00047-14. PMID 24667706.
Menachery VD, Yount BL, Josset L, Gralinski LE, Scobey T, Agnihothram S, Katze M, Baric RS. Attenuation and Restoration of SARS-CoV Mutant lacking 2’O Methyltransferase Activity. J Virol. 2014 Apr;88(8):4251-64. PMID 24478444.
2013
Agnihothram S, Gopal R, Yount B Jr, Donaldon EF, Menachery VD, Graham RL, Scobey TD, Gralinski LE, Denison MR, Zambon M, Baric RS. 2013. Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses. J Infect Dis. 2013 Dec 30. PMID 24253287.
Scobey T, Yount BL, Sims AC, Donaldson EF, Agnihothram SS, Menachery VD, Graham RL, Swanstrom J, Bove PF, Kim JD, Grego S, Randell SH, Baric RS. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62. PMID 24043791.
Menachery VD, Baric RS. Bugs in the System. Immunol Rev. 2013 Sep: 255(1):256-74. PMID 2394736.
Gralinski LE, Bankhead A, Jeng S, Menachery VD, Proll S, Belisle SE, Matzke M, Webb-Robertson BJ, Luna ML, Shukla AK, Ferris MT, Bolles M, Chang J, Aicher L, Waters KM, Smith RD, Metz TO, Law GL, Katze MG, McWeeney S, Baric RS. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. MBio. 2013 Aug 6;4(4). PMID 23919993.
Menachery VD*, Josset L*, Gralinski LE, Agnihothram S, Sova P, Carter VS, Yount BL, Graham RL, Baric RS, Katze MG. Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus. MBio. 2013 Apr 30; 4(3). *Co-first authors. PMID 23631916.
Sims AC, Tilton SC, Menachery VD, Gralinski LE, Schäfer A, Matzke MM, Webb-Robertson BJ, Chang J, Luna ML, Long CE, Shukla AK, Bankhead AR 3rd, Burkett SE, Zornetzer G, Tseng CT, Metz TO, Pickles R, McWeeney S, Smith RD, Katze MG, Waters KM, Baric RS. Release of SARS-CoV nuclear import block enhances host transcription in human lung cells. J Virol. 2013 Apr; 87(7):3885-902. PMID 23365422.
2008-2012
Pasieka, TJ, Menachery VD, Rosato PC, Leib DA. Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus type 1 in the absence of virion host shutoff. J Virol. 2012 Jul; 86(14):7692-5. PMID 22553331.
Menachery VD, Pasieka TJ, Leib DA. Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection. J Virol. 2010 Oct; 84(19): 9685-94. Epub 2010 Jul 21. PMID 20660188.
Menachery VD, Leib DA. Control of herpes simplex virus replication is mediated through an IRF-3 dependent pathway. J Virol. 2009 Dec; 83(23): 12399-406. PMID 19759149.
Pasieka TJ, Lu B, Crosby SD, Wylie KM, Morrison LA, Alexander DE, Menachery VD, Leib DA. Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state. J Virol. 2008 Jun;82(11):5527-35. PMID 18367525.